A new systematic review of 23 trials published by investigators from the Cochranne Collaboration evaluated 4,213 patients who were on antibiotics treatment for different reasons. Researchers concluded that 2% of patients when given probiotics developed C. difficile, compared with 6% of patients who were taking placebo. Additionally, people taking probiotics developed less abdominal side efeects compared to placebo. However, despite the preventive effect on diarrhea, taking probiotics did not entirely eliminate infections with C. difficile.What other indications do you recommend probiotics for? How do you feel about single versus multi-strain products?
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A meta-analysis published in the Annals of Internal Medicine, reports that probiotics may prevent Clostridium difficile–associated diarrhea (CDAD) in patients taking antibiotics. Data was pooled from 20 randomized controlled clinical trials evaluating probiotics compared to placebo or no treatment and the occurrence of CDAD. The results indicated that the occurrence of CDAD was decreased by 66% in those taking probiotics. What questions have you received from patients about the use of probiotics? What other indications do you recommend probiotics for?
For more information, please read the article in the Annals of Internal Medicine.